Signal-peptide predictions across the human proteome

20,416 reviewed UniProt entries scored by two ESM-C 600M classifiers (full-protein and mature-protein training schemes) and SignalP 6.0, alongside UniProt SP/TM annotations. 527 positives (sp_strict_no_tm), 13,065 negatives (no_sp_no_tm), 6,824 outside the labeled pool. SignalP 6.0 currently covers 20,391 entries; the rest are pending.

Thresholds (call = prob > threshold)

Full Mature SignalP 6.0

Definitions

SP = Y if evidence ∈ AND

SP-strict = Y if evidence ∈ AND

20,416 results

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UniProt	Gene	Length	TM #	TM class	GPCR	SP	SP-strict	SP evidence	Full	Mature	SignalP6	Label	Split
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